Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gualou Huoxue Jiedu Decoction inhibits VSMC phenotypic switching to alleviate atherosclerosis via promoting Mfap4 DNA methylation.

Phytomedicine : international journal of phytotherapy and phytopharmacology - 1 Apr 2026

Li Yiming, Zou Wenxin, Zhang Yan, Qi Zhongwen, Wang Qing, Jia Zijun, Zhou Qingbing, Xu Fengqin

Abstract excerpt

BACKGROUND: Atherosclerosis (AS) is a chronic disease characterized by lipid deposition in the vascular intima. As the pathological basis of cardiovascular diseases, AS represents a major contributor to global morbidity and mortality. While Gualou Huoxue Jiedu Decoction (GHJD) has been widely used in clinical practice for the treatment of AS, the molecular mechanisms remain unclear. PURPOSE: To investigate the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoproteins E
Share to Atherosclerosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Drugs, Chinese Herbal

Share to Lipid Metabolism

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Share to Plaque, Atherosclerotic

Source

Identifiers

PMID: 41687536
DOI: 10.1016/j.phymed.2026.157881

Genes

MFAP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gualou Huoxue Jiedu Decoction inhibits VSMC phenotypic switching to alleviate atherosclerosis via promoting Mfap4 DNA methylation.PMID 41687536Read ↗

Silencing METTL3 Stabilizes Atherosclerotic Plaques by Regulating the Phenotypic Transformation of Vascular Smooth Muscle Cells via the miR-375-3p/PDK1 Axis.Semantic proximity Read ↗

DNA Methylation in Atherosclerosis: A New PerspectiveSemantic proximity Read ↗

Epidrugs in the clinical management of atherosclerosis: Mechanisms, challenges and promisesSemantic proximity Read ↗

Comprehensive Multimodal Profiling of Atherosclerosis Reveals Bhlhe40 as a Potential Regulator of Vascular Smooth Muscle Cell Phenotypic ModulationSemantic proximity Read ↗

Modular PheWAS reveals the therapeutic heterogeneity landscape of Danghong injection on stable angina pectoris.Semantic proximity Read ↗

Effects and mechanisms of Zhizi Chuanxiong herb pair against atherosclerosis: an integration of network pharmacology, molecular docking, and experimental validationSemantic proximity Read ↗

UFM1 suppresses VSMCs phenotypic switching and attenuates atherosclerosis by inhibiting AKT phosphorylation.Semantic proximity Read ↗

Identification of PSMA4 as a Therapeutic Target for Atherosclerosis: A Comprehensive Multiomics Mendelian Randomization Analysis.Semantic proximity Read ↗

ATF3 Deficiency Exacerbates Ageing‐Induced Atherosclerosis and Clinical Intervention StrategySemantic proximity Read ↗

Histone Lysine Methylation Modification and Its Role in Vascular CalcificationSemantic proximity Read ↗

Efficacy, safety and mechanism of Simiaoyongan decoction in the treatment of carotid atherosclerotic plaque: a randomized, double-blind, placebo-controlled clinical trial protocolSemantic proximity Read ↗

Research on the correlation between methyltransferase METTL7B and atherosclersosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.