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Vascular cellular senescence in human atherosclerosis: The critical modulating roles of CDKN2A and CDK4/6 signaling pathways

3 Apr 2025

Abstract excerpt

Vascular cellular senescence promotes vascular aging and atherogenesis. Mitigating vascular cellular senescence serves as a promising therapy for atherosclerosis. Transcriptomic analysis was conducted to reveal the differentially expressed genes (DEGs) regulating cell proliferation, growth, senescence, and death in human atherosclerotic lesions vs. normal vessels. The key DEGs were screened out using Venn...

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PMID: 40185315
DOI: 10.1016/j.bcp.2025.116916

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