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Article

Quercetin Attenuates KLF4-Mediated Phenotypic Switch of VSMCs to Macrophage-like Cells in Atherosclerosis: A Critical Role for the JAK2/STAT3 Pathway.

International journal of molecular sciences - 15 Jul 2024

Xiang Lu, Wang Yan, Liu Si, Ying Linyao, Zhang Keyi, Liang Na, Li Hao, Luo Gang, Xiao Lin

Abstract excerpt

The objective of this study was to elucidate the protective role of quercetin in atherosclerosis by examining its effect on the phenotypic switch of vascular smooth muscle cells (VSMCs) to macrophage-like cells and the underlying regulatory pathways. Aorta tissues from apolipoprotein E-deficient (ApoE KO) mice fed a high-fat diet (HFD), treated with or without 100 mg/kg/day quercetin, were analyzed for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39062998
DOI: 10.3390/ijms25147755
PMCID: PMC11277168

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