Article
JIB-04, a histone demethylase Jumonji C domain inhibitor, regulates phenotypic switching of vascular smooth muscle cells.
Clinical epigenetics - 13 Aug 2022
He Yi, Yi Xin, Zhang Zihao, Luo Hanshen, Li Rui, Feng Xin, Fang Ze-Min, Zhu Xue-Hai, Cheng Wenlin, Jiang Ding-Sheng, Zhao Fang, Wei Xiang
Abstract excerpt
BACKGROUND: Vascular smooth muscle cell (VSMC) phenotype switching is critical for neointima formation, which is the major cause of restenosis after stenting or coronary artery bypass grafting. However, the epigenetic mechanisms regulating phenotype switching of VSMCs, especially histone methylation, are not well understood. As a main component of histone lysine demethylases, Jumonji demethylases might be...
Topics
- Aminopyridines
- Animals
- Cell Movement
- Cell Proliferation
- DNA Methylation
- Disease Models, Animal
- Histone Demethylases
- Histones
- Hydrazones
- Mice
- Muscle, Smooth, Vascular