Article
Deficiency of protein inhibitor of activated STAT3 exacerbates atherosclerosis by modulating VSMC phenotypic switching.
Atherosclerosis - 1 Sept 2023
Liu Haole, Zhang Jingyi, Xue Ziyang, Chang Mingke, Feng Xinxin, Cai Yifan, Bai Liang, Wang Weirong, Liu Enqi, Zhao Sihai, Wang Rong
Abstract excerpt
BACKGROUND AND AIMS: Phenotypic switching of vascular smooth muscle cells (VSMCs) plays an essential role in the development of atherosclerosis. Protein inhibitor of activated STAT (Pias) regulates VSMCs phenotype via acting as sumo E3 ligase to promote protein sumoylation. Our previous study indicated that Pias3 expression decreased in atherosclerotic lesions. Therefore, this study aimed to explore the role of...
Topics
- Mice
- Animals
- Vimentin
- Muscle, Smooth, Vascular
- Atherosclerosis
- Phenotype
- Apolipoproteins E
- Myocytes, Smooth Muscle
- Cell Proliferation
- Cells, Cultured