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Article

Molecular Mechanisms and Therapeutic Targeting of the STAT3 Signaling Axis in Vascular Smooth Muscle Cell Phenotypic Switching and Vascular Remodeling.

Cells - 7 Sept 2026

Zheng Tingxuan, Li Haomin, Yao Long, Zhang Yiqian, Feng Lingran, Yang Dongmei

Abstract excerpt

Vascular smooth muscle cells (VSMCs) exhibit remarkable phenotypic plasticity, dynamically transitioning from a quiescent contractile state to a dedifferentiated synthetic phenotype that constitutes the fundamental cytological driver of pathological vascular remodeling in cardiovascular diseases (CVDs) including atherosclerosis, vascular restenosis, aortic dissection (AD), and vascular calcification (VC). Signal...

Read the complete abstract on PubMed

Topics

STAT3 Transcription Factor
Humans
Muscle, Smooth, Vascular
Vascular Remodeling
Signal Transduction
Animals

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Phenotype

Myocytes, Smooth Muscle

Source

Open in PubMed Open full text

Identifiers

PMID: 42738917
DOI: 10.3390/cells15171624
PMCID: PMC13564690

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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