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Article

Piperlonguminine attenuates atherosclerosis in mice via phenotype switching inhibition of vascular smooth muscle cells.

European journal of pharmacology - 28 May 2026

Sun Yun, Zhu Defen, Luo Xumei, Ren Zizai, Yang Xuemei, Du Wenxia, Wang Mengyan, Hu Yingte, Rao Gaoxiong, Wu Xiangnong, Zhuang Xinying, Huang Feng, Tong Xiaoyun

Abstract excerpt

Phenotypic switching of vascular smooth muscle cells (VSMCs) plays diverse roles in the development of atherosclerosis. These cells are a primary contributor to plaque formation and can transition between contractile and synthetic states in response to inflammation or oxidized low-density lipoproteins, exacerbating atherosclerosis. Piperlonguminine (PLG), a bioactive compound obtained from Piper longum L., is...

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Identifiers

PMID: 42067016
DOI: 10.1016/j.ejphar.2026.178908

Genes

PLG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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