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Article

E2F5 Accelerates Vascular Smooth Muscle Cells Phenotype Switching in Diabetic Atherosclerosis through Activating Wnt/β-Catenin Pathway.

Diabetes & metabolism journal - 1 May 2026

Di Mingxue, Wang Jie, Sun Lin, Yang Guang, Xu Qun

Abstract excerpt

BACKGRUOUND: We determined the precise function of E2F transcription factor 5 (E2F5) on the development of diabetic atherosclerosis (DAS) and the underlying mechanisms. METHODS: Apolipoprotein E-knockout mice were intraperitoneally injected with streptozotocin for 5 days and fed a high-fat diet for 12 weeks for establishing an in vivo DAS model. To establish a DAS vascular smooth muscle cells (VSMCs) model, VSMCs...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Experimental

Share to Diabetic Angiopathies

Share to Mice, Knockout, ApoE

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Share to Wnt Signaling Pathway

Source

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Identifiers

PMID: 40890020
DOI: 10.4093/dmj.2024.0588
PMCID: PMC13175694

Genes

E2F5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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