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Article

Silencing METTL3 Stabilizes Atherosclerotic Plaques by Regulating the Phenotypic Transformation of Vascular Smooth Muscle Cells via the miR-375-3p/PDK1 Axis.

Cardiovascular drugs and therapy - 1 Jun 2023

Chen Jingquan, Lai Kun, Yong Xi, Yin Hongshun, Chen Zhilong, Wang Haifei, Chen Kai, Zheng Jianghua

Abstract excerpt

PURPOSE: Atherosclerosis (AS) is a primary cause of cardiovascular diseases. This study investigated the mechanism of methyltransferase-like 3 (METTL3) in AS plaques via modulating the phenotypic transformation of vascular smooth muscle cells (VSMCs). METHODS: AS mouse models and MOVAS cell models were established through high-fat diet and the treatment of ox-LDL, respectively. METTL3 expression in AS models was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35704246
DOI: 10.1007/s10557-022-07348-6

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