Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

AMPKα-like proteins as LKB1 downstream targets in cell physiology and cancer.

Journal of molecular medicine (Berlin, Germany) - 1 May 2021

Molina Ester, Hong Linda, Chefetz IIana

Abstract excerpt

One of the key events in cancer development is the ability of tumor cells to overcome nutrient deprivation and hypoxia. Among proteins performing metabolic adaptation to the various cellular nutrient conditions, liver kinase B 1 (LKB1) and its main downstream target adenosine monophosphate (AMP)-activated protein kinase α (AMPKα) are important sensors of energy requirements within the cell. Although LKB1 was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AMP-Activated Protein Kinase Kinases
Share to AMP-Activated Protein Kinases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Polarity

Share to Enzyme Activation

Share to Neoplasms

Share to Protein Kinases

Share to Protein Serine-Threonine Kinases

Share to Repressor Proteins

Source

Identifiers

PMID: 33661342
DOI: 10.1007/s00109-021-02040-y

Genes

BRSK1
MARK1
MARK2
MARK3
MARK4
MELK
NUAK1
SIK1
SIK2
SIK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

AMPKα-like proteins as LKB1 downstream targets in cell physiology and cancer.PMID 33661342Read ↗

NUAK Kinases: Brain-Ovary Axis.Semantic proximity Read ↗

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.Semantic proximity Read ↗

Controlling the master-upstream regulation of the tumor suppressor LKB1.Semantic proximity Read ↗

LKB1 deficiency-induced metabolic reprogramming in tumorigenesis and non-neoplastic diseases.Semantic proximity Read ↗

Unravelling the connection between metabolism and tumorigenesis through studies of the liver kinase B1 tumour suppressorSemantic proximity Read ↗

Insights into targeting LKB1 in tumorigenesisSemantic proximity Read ↗

The role of STK11/LKB1 in cancer biology: implications for ovarian tumorigenesis and progressionSemantic proximity Read ↗

LKB1-AMPK axis revisited.Semantic proximity Read ↗

Molecular insights and therapeutic implications for the tumor suppressor role of LKB1 in non-small cell lung cancer.Semantic proximity Read ↗

Evidence of cancer-promoting roles for AMPK and related kinases.Semantic proximity Read ↗

AMP-activated protein kinase – not just an energy sensorSemantic proximity Read ↗

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.