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Article

Controlling the master-upstream regulation of the tumor suppressor LKB1.

Oncogene - 1 Jun 2018

Kullmann Lars, Krahn Michael P

Abstract excerpt

The tumor suppressor LKB1 is an essential serine/threonine kinase, which regulates various cellular processes such as cell metabolism, cell proliferation, cell polarity, and cell migration. Germline mutations in the STK11 gene (encoding LKB1) are the cause of the Peutz-Jeghers syndrome, which is characterized by benign polyps in the intestine and a higher risk for the patients to develop intestinal and...

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Source

Identifiers

PMID: 29540834
DOI: 10.1038/s41388-018-0145-z

Genes

STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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