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Article

Evidence of cancer-promoting roles for AMPK and related kinases.

The FEBS journal - 1 Dec 2015

Monteverde Tiziana, Muthalagu Nathiya, Port Jennifer, Murphy Daniel J

Abstract excerpt

The discovery that the 5'AMP-activated protein kinase (AMPK) serves to link the tumour suppressors LKB1 and the tuberous sclerosis complex and functions to slow macromolecular synthesis through attenuation of the mechanistic target of rapamycin complex 1 revealed a role for AMPK in tumour suppression. On the other hand, the well-recognized role of AMPK in maintaining ATP homeostasis, through suppression of...

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PMID: 26426570
DOI: 10.1111/febs.13534

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