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The role of STK11/LKB1 in cancer biology: implications for ovarian tumorigenesis and progression

31 Oct 2024

Abstract excerpt

STK11 (serine-threonine kinase 11), also known as LKB1 (liver kinase B1) is a highly conserved master kinase that regulates cellular metabolism and polarity through a complex signaling network involving AMPK and 12 other AMPK-related kinases. Germline mutations in LKB1 have been causatively linked to Peutz-Jeghers Syndrome (PJS), an autosomal dominant hereditary disease with high cancer susceptibility. The...

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PMID: 39544365
DOI: 10.3389/fcell.2024.1449543

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