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Insights into targeting LKB1 in tumorigenesis

28 Aug 2024

Abstract excerpt

Genetic alterations to serine-threonine kinase 11 ( STK11 ) have been implicated in Peutz-Jeghers syndrome and tumorigenesis. Further exploration of the context-specific roles of liver kinase B1 (LKB1; encoded by STK11 ) observed that it regulates AMP-activated protein kinase (AMPK) and AMPK-related kinases. Given that both migration and proliferation are enhanced with the loss of LKB1 activity combined with the...

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PMID: 39735555
DOI: 10.1016/j.gendis.2024.101402

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