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Article

Unravelling the connection between metabolism and tumorigenesis through studies of the liver kinase B1 tumour suppressor

1 Jan 2013

Abstract excerpt

The liver kinase B1 (LKB1) tumour suppressor functions as a master regulator of growth, metabolism and survival in cells, which is frequently mutated in sporadic human non-small cell lung and cervical cancers. LKB1 functions as a key upstream activator of the AMP-activated protein kinase (AMPK), a central metabolic switch found in all eukaryotes that govern glucose and lipid metabolism and autophagy in response...

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PMID: 24082825
DOI: 10.4103/1477-3163.116323

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