Article
Molecular insights and therapeutic implications for the tumor suppressor role of LKB1 in non-small cell lung cancer.
Cancer letters - 28 Sept 2026
Yan Peiqiang, Jiang Weiwei, Xue Xutong, Hou Tao, Wang Jingchao, Huang Daoyuan, Chen Li, Inuzuka Hiroyuki, Dai Xiaoming, Wei Wenyi
Abstract excerpt
As a master serine/threonine kinase, LKB1 phosphorylates a network of downstream kinases that regulate energy homeostasis, polarity, and cellular stress adaptation. As such, LKB1 functions as a pivotal tumor suppressor in non-small cell lung cancer (NSCLC). Mutations, deletions, or other disruptions of LKB1 biological functions occur in 20-30% of NSCLC. Loss of LKB1 kinase activity impairs energy and metabolic...
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