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Article

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.

Cell metabolism - 1 Jan 2005

Kahn Barbara B, Alquier Thierry, Carling David, Hardie D Grahame

Abstract excerpt

The AMP-activated protein kinase (AMPK) is an evolutionarily conserved sensor of cellular energy status, and recent data demonstrate that it also plays a critical role in systemic energy balance. AMPK integrates nutritional and hormonal signals in peripheral tissues and the hypothalamus. It mediates effects of adipokines (leptin, adiponectin, and possibly resistin) in regulating food intake, body weight, and...

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Identifiers

PMID: 16054041
DOI: 10.1016/j.cmet.2004.12.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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