Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

LKB1-AMPK axis revisited.

Cell research - 1 Dec 2012

Kottakis Filippos, Bardeesy Nabeel

Abstract excerpt

The LKB1 tumor suppressor encodes a serine-threonine kinase whose substrates control cell metabolism, polarity, and motility. LKB1 is a major mediator of the cellular response to energy stress via activation of the master regulator of energy homeostasis, AMPK. While mutational inactivation of LKB1 promotes the development of many types of epithelial cancer, a recent report in Nature by Jeon et al. demonstrates...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetyl-CoA Carboxylase
Share to Acetyltransferases
Share to AMP-Activated Protein Kinase Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to AMP-Activated Protein Kinases

Share to Energy Metabolism

Share to Oxidative Stress

Share to TOR Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 22801477
DOI: 10.1038/cr.2012.108
PMCID: PMC3515750

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LKB1-AMPK axis revisited.PMID 22801477Read ↗

LKB1 and cancer: The dual role of metabolic regulation.Semantic proximity Read ↗

Controlling the master-upstream regulation of the tumor suppressor LKB1.Semantic proximity Read ↗

Unravelling the connection between metabolism and tumorigenesis through studies of the liver kinase B1 tumour suppressorSemantic proximity Read ↗

Role of the LKB1/AMPK pathway in tumor invasion and metastasis of cancer cells (Review)Semantic proximity Read ↗

LKB1 tumor suppressor: Therapeutic opportunities knock when LKB1 is inactivatedSemantic proximity Read ↗

Liver kinase B1 (LKB1) in the pathogenesis of epithelial cancers.Semantic proximity Read ↗

LKB1 deficiency-induced metabolic reprogramming in tumorigenesis and non-neoplastic diseases.Semantic proximity Read ↗

The molecular mechanisms that underlie the tumor suppressor function of LKB1.Semantic proximity Read ↗

The role of STK11/LKB1 in cancer biology: implications for ovarian tumorigenesis and progressionSemantic proximity Read ↗

Molecular insights and therapeutic implications for the tumor suppressor role of LKB1 in non-small cell lung cancer.Semantic proximity Read ↗

AMPKα-like proteins as LKB1 downstream targets in cell physiology and cancer.Semantic proximity Read ↗

LKB1 and AMPK Family Signaling: The Intimate Link Between Cell Polarity and Energy MetabolismSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.