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Article

LKB1 deficiency-induced metabolic reprogramming in tumorigenesis and non-neoplastic diseases.

Molecular metabolism - 1 Feb 2021

Zhang Yanghe, Meng Qingfei, Sun Qianhui, Xu Zhi-Xiang, Zhou Honglan, Wang Yishu

Abstract excerpt

BACKGROUND: Live kinase B1 (LKB1) is a tumor suppressor that is mutated in Peutz-Jeghers syndrome (PJS) and a variety of cancers. Lkb1 encodes serine-threonine kinase (STK) 11 that activates AMP-activated protein kinase (AMPK) and its 13 superfamily members, regulating multiple biological processes, such as cell polarity, cell cycle arrest, embryo development, apoptosis, and bioenergetics metabolism. Increasing...

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Identifiers

PMID: 33278637
DOI: 10.1016/j.molmet.2020.101131
PMCID: PMC7753952

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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