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Article

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.

The EMBO journal - 25 Feb 2004

Lizcano Jose M, Göransson Olga, Toth Rachel, Deak Maria, Morrice Nick A, Boudeau Jérôme, Hawley Simon A, Udd Lina, Mäkelä Tomi P, Hardie D Grahame, Alessi Dario R

Abstract excerpt

We recently demonstrated that the LKB1 tumour suppressor kinase, in complex with the pseudokinase STRAD and the scaffolding protein MO25, phosphorylates and activates AMP-activated protein kinase (AMPK). A total of 12 human kinases (NUAK1, NUAK2, BRSK1, BRSK2, QIK, QSK, SIK, MARK1, MARK2, MARK3,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 14976552
DOI: 10.1038/sj.emboj.7600110
PMCID: PMC381014

Genes

MARK1
MARK2
MARK4
MELK
NUAK2
BRSK1
BRSK2
MARK3
NUAK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14976552-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.PMID 14976552Read ↗

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