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AMP-activated protein kinase – not just an energy sensor

2017-09-22

Abstract excerpt

Orthologues of AMP-activated protein kinase (AMPK) occur in essentially all eukaryotes as heterotrimeric complexes comprising catalytic α subunits and regulatory β and γ subunits. The canonical role of AMPK is as an energy sensor, monitoring levels of the nucleotides AMP, ADP, and ATP that bind competitively to the γ subunit. Once activated, AMPK acts to restore energy homeostasis by switching on alternate ATP-gen...

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Identifiers and source

Literature Corpus work
172cb009-385d-55c6-a65b-ce4aae1ce727
DOI
10.12688/f1000research.11960.1
Open publication

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AMP-activated protein kinase – not just an energy sensorDOI 10.12688/f1000research.11960.1
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