Article
Increased APOE ε4 expression is associated with the difference in Alzheimer's disease risk from diverse ancestral backgrounds.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jul 2021
Griswold Anthony J, Celis Katrina, Bussies Parker L, Rajabli Farid, Whitehead Patrice L, Hamilton-Nelson Kara L, Beecham Gary W, Dykxhoorn Derek M, Nuytemans Karen, Wang Liyong, Gardner Olivia K, Dorfsman Daniel A, Bigio Eileen H, Mesulam Marek Marsel, Weintraub Sandra, Geula Changiz, Gearing Marla, McGrath-Martinez Elisa, Dalgard Clifton L, Scott William K, Haines Jonathan L, Pericak-Vance Margaret A, Young Juan I, Vance Jeffery M
Abstract excerpt
INTRODUCTION: Apolipoprotein E (APOE) ε4 confers less risk for Alzheimer's disease (AD) in carriers with African local genomic ancestry (ALA) than APOE ε4 carriers with European local ancestry (ELA). Cell type specific transcriptional variation between the two local ancestries (LAs) could contribute to this disease risk differences. METHODS: Single-nucleus RNA sequencing was performed on frozen frontal cortex of...
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