Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cell subtype-specific effects of genetic variation in the Alzheimer's disease brain.

Nature genetics - 1 Apr 2024

Fujita Masashi, Gao Zongmei, Zeng Lu, McCabe Cristin, White Charles C, Ng Bernard, Green Gilad Sahar, Rozenblatt-Rosen Orit, Phillips Devan, Amir-Zilberstein Liat, Lee Hyo, Pearse Richard V, Khan Atlas, Vardarajan Badri N, Kiryluk Krzysztof, Ye Chun Jimmie, Klein Hans-Ulrich, Wang Gao, Regev Aviv, Habib Naomi, Schneider Julie A, Wang Yanling, Young-Pearse Tracy, Mostafavi Sara, Bennett David A, Menon Vilas, De Jager Philip L

Abstract excerpt

The relationship between genetic variation and gene expression in brain cell types and subtypes remains understudied. Here, we generated single-nucleus RNA sequencing data from the neocortex of 424 individuals of advanced age; we assessed the effect of genetic variants on RNA expression in cis (cis-expression quantitative trait loci) for seven cell types and 64 cell subtypes using 1.5 million transcriptomes. This...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Genome-Wide Association Study

Share to Membrane Proteins

Share to Nerve Tissue Proteins

Share to Quantitative Trait Loci

Source

Identifiers

PMID: 38514782
DOI: 10.1038/s41588-024-01685-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cell subtype-specific effects of genetic variation in the Alzheimer's disease brain.PMID 38514782Read ↗

Cell-type-specific cis-eQTLs in eight human brain cell types identify novel risk genes for psychiatric and neurological disorders.Semantic proximity Read ↗

Cell-type specific cis-eQTLs in eight brain cell-types identifies novel risk genes for human brain disordersSemantic proximity Read ↗

A single-cell atlas of entorhinal cortex from individuals with Alzheimer's disease reveals cell-type-specific gene expression regulation.Semantic proximity Read ↗

High cell-type specificity of eQTLs revealed by single-nucleus analyses of brain and bloodSemantic proximity Read ↗

Single-cell RNA sequencing analysis of human Alzheimer’s disease brain samples reveals neuronal and glial specific cells differential expressionSemantic proximity Read ↗

A single cell brain atlas in human Alzheimer’s diseaseSemantic proximity Read ↗

Human brain single nucleus cell type enrichments in neurodegenerative diseasesSemantic proximity Read ↗

Molecular and cellular pathology of monogenic Alzheimer’s disease at single cell resolutionSemantic proximity Read ↗

Disease-specific selective vulnerability and neuroimmune pathways in dementia revealed by single cell genomicsSemantic proximity Read ↗

The Landscape of Sex- and APOE Genotype-Specific Transcriptional Changes in Alzheimer’s Disease at the Single Cell LevelSemantic proximity Read ↗

Single-cell transcriptomic analysis elucidates APOE genotype specific changes across cell types in two brain regions in Alzheimer’s diseaseSemantic proximity Read ↗

Cell type-specific associations with Alzheimer’s Disease conserved across racial and ethnic groupsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.