Article

Single-Nuclei Transcriptomic Characterization of <i>APOE4</i> -Associated Alzheimer’s Disease

2026-04-04

Abstract excerpt

<h4>ABSTRACT</h4> Apolipoprotein E ( APOE ) genotype contributes significantly to Alzheimer’s disease (AD) risk and pathogenesis. Cell-type specific effects of APOE alleles have been studied. However, due to the variable prevalence of APOE genotypes within human populations, characterization of cell-type specific transcriptomes across APOE genotypes has been challenging. Here, we integrated previous and newly...

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Literature Corpus work: 7e6dc5c5-730e-5c4a-b13f-0eab5cd0a4d1
DOI: 10.64898/2026.04.03.715591

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