Article

Converging evidence for differential regulatory control of <i>APOEε4</i> on African versus European haplotypes

2021-08-24

Abstract excerpt

<h4>INTRODUCTION</h4> The difference in APOEε4 risk for Alzheimer disease (AD) between different populations is associated with APOEε4 local ancestry (LA). We examined LA SNPs with significant frequency differences between African and European/Japanese APOEε4 haplotypes for areas of differential regulation. <h4>METHODS</h4> We performed two enhancer Massively Parallel Reporter Assay (MPRA) approaches, supple...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 31f17232-b4ea-5383-9eea-011963b0be28
DOI: 10.1101/2021.08.23.457375

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Converging evidence for differential regulatory control of <i>APOEε4</i> on African versus European haplotypesDOI 10.1101/2021.08.23.457375Read

Identifying differential regulatory control of APOE ɛ4 on African versus European haplotypes as potential therapeutic targets.Semantic proximity Read

A common 19 bp APOE enhancer deletion is protective against Alzheimer's disease in African Americans.Semantic proximity Read

Comparative gene regulatory networks modulating <i>APOE</i> expression in microglia and astrocytesSemantic proximity Read

Functional analysis of APOE locus genetic variation implicates regional enhancers in the regulation of both TOMM40 and APOE.Semantic proximity Read

The <i>APOE</i> isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia in a xenotransplantation model of Alzheimer’s diseaseSemantic proximity Read

An Alzheimer’s disease-associated common regulatory variant in a PTK2B intron alters microglial functionSemantic proximity Read

Ancestry-related differences in chromatin accessibility and gene expression of <i>APOE4</i> are associated with Alzheimer disease riskSemantic proximity Read

Genetics of the human microglia regulome refines Alzheimer’s disease risk lociSemantic proximity Read

Increased <i>APOEε4</i> expression is associated with reactive A1 astrocytes and the difference in Alzheimer Disease risk from diverse ancestral backgroundsSemantic proximity Read

Association of Rare <i>APOE</i> Missense Variants R189C and W276C With Risk of Alzheimer DiseaseSemantic proximity Read

<i>APOE</i>missense variant R145C is associated with increased Alzheimer’s disease risk in African ancestry individuals with the<i>APOE ε3/ε4</i>genotypeSemantic proximity Read

Commentary on 'Functional analysis of APOE locus genetic variation implicates regional enhancers in the regulation of both TOMM40 and APOE'.Semantic proximity Read