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Increased <i>APOEε4</i> expression is associated with reactive A1 astrocytes and the difference in Alzheimer Disease risk from diverse ancestral backgrounds

2020-03-11

Abstract excerpt

APOEε4 African local genomic ancestry (LA) confers less risk for Alzheimer disease (AD) relative to European LA (LA) carriers. Single nucleus RNA sequencing from AD- APOEε4/4 frontal cortex found European LA carriers have a 1.45-fold greater APOEε4 expression (p< 1.8 E10 −313 ) and are associated with a unique A1 reactive astrocyte cluster. This suggests a potential mechanism for the increased risk for AD seen...

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Literature Corpus work
75499550-d62c-5db5-bdf9-c74fd86903a5
DOI
10.1101/2020.03.09.983817
Open publication

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Increased <i>APOEε4</i> expression is associated with reactive A1 astrocytes and the difference in Alzheimer Disease risk from diverse ancestral backgroundsDOI 10.1101/2020.03.09.983817
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