APOE genotype determines cell-type-specific pathological landscape of Alzheimer's disease.

doi:10.1016/j.neuron.2025.02.017

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Article

APOE genotype determines cell-type-specific pathological landscape of Alzheimer's disease.

Neuron - 7 May 2025

Li Zonghua, Martens Yuka A, Ren Yingxue, Jin Yunjung, Sekiya Hiroaki, Doss Sydney V, Kouri Naomi, Castanedes-Casey Monica, Christensen Trace A, Miller Nevalainen Lindsay B, Takegami Nanaka, Chen Kai, Liu Chia-Chen, Soto-Beasley Alexandra, Boon Baayla D C, Labuzan Sydney A, Ikezu Tadafumi C, Chen Yixing, Bartkowiak Alexander D, Xhafkollari Gisela, Wetmore Allison M, Bennett David A, Reichard Ross R, Petersen Ronald C, Kanekiyo Takahisa, Ross Owen A, Murray Melissa E, Dickson Dennis W, Bu Guojun, Zhao Na

Abstract excerpt

The apolipoprotein E (APOE) gene is the strongest genetic risk modifier for Alzheimer's disease (AD), with the APOE4 allele increasing risk and APOE2 decreasing it compared with the common APOE3 allele. Using single-nucleus RNA sequencing of the temporal cortex from APOE2 carriers, APOE3 homozygotes, and APOE4 carriers, we found that AD-associated transcriptomic changes were highly APOE genotype dependent....

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Identifiers

PMID: 40112813
DOI: 10.1016/j.neuron.2025.02.017
PMCID: PMC12333916

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APOE

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