Back to search

Article

Single-nucleus multiomics in brains from Hispanic individuals reveal<i>APOE-ε4</i>-driven disruption of focal adhesion signaling in the presence of cerebrovascular pathology

2025-05-21

Abstract excerpt

The apolipoprotein E ε4 allele ( APOE-ε4 ) is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD), yet its molecular impact on cerebrovascular biology remains inconclusive, particularly in underrepresented populations with elevated vascular burden. Individuals from Hispanic ancestry experience disproportionately high rates of cerebrovascular pathology, offering a unique opportunity to investi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
df1065be-b689-5588-965e-b4431d65a3be
DOI
10.1101/2025.05.21.25328040
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Single-nucleus multiomics in brains from Hispanic individuals reveal<i>APOE-ε4</i>-driven disruption of focal adhesion signaling in the presence of cerebrovascular pathologyDOI 10.1101/2025.05.21.25328040
Single-Nuclei Transcriptomic Characterization of <i>APOE4</i> -Associated Alzheimer’s DiseaseSemantic proximity
APOE4 promotes cerebrovascular fibrosis and amyloid deposition via a pericyte-to-myofibroblast transitionSemantic proximity
APOE genotype determines cell-type-specific pathological landscape of Alzheimer's disease.Semantic proximity
A single cell brain atlas in human Alzheimer’s diseaseSemantic proximity
Cerebrovascular Single-Nucleus RNA-Seq Reveals Heat Shock Activation and Vascular Remodeling in Alzheimer’s Disease and Primary TauopathiesSemantic proximity
Inflammatory reprogramming of human brain endothelial cells compromises blood–brain barrier integrity in Alzheimer’s diseaseSemantic proximity
Cell type-specific associations with Alzheimer’s Disease conserved across racial and ethnic groupsSemantic proximity
Single Nuclei Transcriptome Reveals Perturbed Brain Vascular Molecules in Alzheimer’s DiseaseSemantic proximity
A human brain vascular atlas reveals diverse cell mediators of Alzheimer’s disease riskSemantic proximity
Cerebrovascular Single-Nucleus RNA-Seq Reveals Heat Shock Activation and Vascular Remodeling in Alzheimer’s Disease and Primary TauopathiesSemantic proximity
Molecular and cellular pathology of monogenic Alzheimer’s disease at single cell resolutionSemantic proximity
Whole-Brain Cell-Cell Interaction Axes Explaining Tissue Vulnerability Across the Neurodegenerative SpectrumSemantic proximity
Select a neighboring publication to make it the new centre.