Article

<i>APOE</i> E4 Alzheimer’s Risk Converges on an Oligodendrocyte Subtype in the Human Entorhinal Cortex

2025-11-20

Abstract excerpt

The entorhinal cortex (ERC) is implicated in early progression of Alzheimer’s disease (AD). Here we investigated the impact of established biological risk factors for AD, including APOE genotype (E2 versus E4 alleles), sex, and ancestry, on gene expression in the human ERC. We generated paired spatially-resolved transcriptomics (SRT) and single-nucleus RNA sequencing data (snRNA-seq) in postmortem human ERC tissu...

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Literature Corpus work: cc4b6594-e122-55bf-94f8-bfa0f0430249
DOI: 10.1101/2025.11.20.689483

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