Article

Ancestry-related differences in chromatin accessibility and gene expression of <i>APOE4</i> are associated with Alzheimer disease risk

2022-10-28

Abstract excerpt

<h4>Background</h4> European local ancestry (ELA) surrounding APOE4 is associated with a higher risk for Alzheimer Disease (AD) compared to African local ancestry (ALA). We previously demonstrated significantly higher APOE4 expression in ELA vs ALA in the frontal cortex of APOE4/4 AD patients. Differences in chromatin accessibility could contribute to these differences in APOE4 expression. <h4>Methods</h4>...

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Literature Corpus work: 437e3af6-ca86-526d-9b20-42f6c8c5b685
DOI: 10.1101/2022.10.27.514114

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