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Ancestry‐related differences in chromatin accessibility and gene expression of APOE ε4 are associated with Alzheimer's disease risk

10 Apr 2023

Abstract excerpt

INTRODUCTION: European local ancestry (ELA) surrounding apolipoprotein E (APOE) ε4 confers higher risk for Alzheimer's disease (AD) compared to African local ancestry (ALA). We demonstrated significantly higher APOE ε4 expression in ELA versus ALA in AD brains from APOE ε4/ε4 carriers. Chromatin accessibility differences could contribute to these expression changes. METHODS: We performed single nuclei assays for...

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PMID: 37037656
DOI: 10.1002/alz.13075

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