Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variants in glutamate-, Aβ-, and tau-related pathways determine polygenic risk for Alzheimer's disease.

Neurobiology of aging - 1 May 2021

Lawingco Ted, Chaudhury Sultan, Brookes Keeley J, Guetta-Baranes Tamar, Guerreiro Rita, Bras Jose, Hardy John, Francis Paul, Thomas Alan, Belbin Olivia, Morgan Kevin

Abstract excerpt

Synapse loss is an early event in late-onset Alzheimer's disease (LOAD). In this study, we have assessed the capacity of a polygenic risk score (PRS) restricted to synapse-encoding loci to predict LOAD. We used summary statistics from the International Genetics of Alzheimer's Project genome-wide association meta-analysis of 74,046 patients for model construction and tested the "synaptic PRS" in 2 independent data...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Alzheimer Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amyloid beta-Peptides

Share to Genome-Wide Association Study

Share to Glutamates

Share to Multifactorial Inheritance

Share to Signal Transduction

Share to tau Proteins

Source

Identifiers

PMID: 33303219
DOI: 10.1016/j.neurobiolaging.2020.11.009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variants in glutamate-, Aβ-, and tau-related pathways determine polygenic risk for Alzheimer's disease.PMID 33303219Read ↗

Alzheimer's disease polygenic risk in early- and late-onset Alzheimer's disease.Semantic proximity Read ↗

Late-Onset Alzheimer's Disease Polygenic Risk Profile Score Predicts Hippocampal Function.Semantic proximity Read ↗

The role of genetic risk factors of Alzheimer's disease in synaptic dysfunctionSemantic proximity Read ↗

Harnessing the paradoxical phenotypes of APOE ɛ2 and APOE ɛ4 to identify genetic modifiers in Alzheimer's disease.Semantic proximity Read ↗

Shared genetic etiology underlying Alzheimer's disease and major depressive disorder.Semantic proximity Read ↗

Association of Whole-Person Eigen-Polygenic Risk Scores with Alzheimer’s DiseaseSemantic proximity Read ↗

Polygenic Risk Score Reveals Genetic Heterogeneity of Alzheimer's Disease between the Chinese and European Populations.Semantic proximity Read ↗

Polygenic risk discriminates Lewy body dementia from Alzheimer's disease.Semantic proximity Read ↗

Association of whole-person eigen-polygenic risk scores with Alzheimer's disease.Semantic proximity Read ↗

Risk prediction of late-onset Alzheimer's disease implies an oligogenic architecture.Semantic proximity Read ↗

Investigation of 15 of the top candidate genes for late-onset Alzheimer's disease.Semantic proximity Read ↗

Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.