Article
Late-Onset Alzheimer's Disease Polygenic Risk Profile Score Predicts Hippocampal Function.
Biological psychiatry. Cognitive neuroscience and neuroimaging - 1 Nov 2017
Xiao Ena, Chen Qiang, Goldman Aaron L, Tan Hao Yang, Healy Kaitlin, Zoltick Brad, Das Saumitra, Kolachana Bhaskar, Callicott Joseph H, Dickinson Dwight, Berman Karen F, Weinberger Daniel R, Mattay Venkata S
Abstract excerpt
BACKGROUND: We explored the cumulative effect of several late-onset Alzheimer's disease (LOAD) risk loci using a polygenic risk profile score (RPS) approach on measures of hippocampal function, cognition, and brain morphometry. METHODS: In a sample of 231 healthy control subjects (19-55 years of age), we used an RPS to study the effect of several LOAD risk loci reported in a recent meta-analysis on hippocampal...
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