Article
Alzheimer's disease polygenic risk in early- and late-onset Alzheimer's disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jan 2026
Pentchev Julian V, Jackson Trever, Khan Naazneen, Rosewood Thea J, Huang Yen-Ning, Nho Kwangsik, Saykin Andrew J, Eloyan Ani, Taurone Alexander, Thangarajah Maryanne, Riddle Meghan, Salloway Steven, Atri Alireza, Honig Lawrence S, Johnson Erik C B, Turner Raymond Scott, Masdeu Joseph C, Foroud Tatiana M, Clark David, Hammers Dustin B, Dage Jeffrey L, Kirby Kala, Ghetti Bernardino, Newell Kathy, Onyike Chiadi U, Day Gregory S, Graff-Radford Neill R, Murray Melissa E, Jones David T, Jack Clifford R, Vemuri Prashanthi, Touroutoglou Alexandra, Duara Ranjan, Grant Ian, Sha Sharon, Wingo Thomas S, Beckett Laurel A, Rogalski Emily, Mendez Mario F, Kramer Joel, La Joie Renaud, Blazhenets Ganna, Grinberg Lea T, Koeppe Robert, Wolk David A, Aisen Paul, Raman Rema, Toga Arthur, Kukull Walter A, Musiek Erik, Womack Kyle B, Carrillo Maria C, Rabinovici Gil D, Dickerson Bradford C, Apostolova Liana G, Nudelman Kelly N H
Abstract excerpt
INTRODUCTION: The genetic basis of sporadic early-onset Alzheimer's disease (EOAD) remains largely unknown, prompting evaluation of late-onset Alzheimer's disease (LOAD) polygenic risk in EOAD. METHODS: A LOAD polygenic score (PGS) was calculated in the Longitudinal Early-onset Alzheimer's Disease Study (LEADS) and Alzheimer's Disease Neuroimaging Initiative (ADNI) study and tested for associations with AD risk,...
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