Article

Association of Whole-Person Eigen-Polygenic Risk Scores with Alzheimer’s Disease

2022-09-15

Abstract excerpt

Late-Onset Alzheimer’s Disease (LOAD) is a heterogeneous neurodegenerative disorder with complex etiology and high heritability. Its multifactorial risk profile and large portions of unexplained heritability suggest the involvement of yet unidentified genetic risk factors. Here we describe the “whole person” genetic risk landscape of polygenic risk scores for 2,218 traits in 2,044 elderly individuals and test if n...

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Literature Corpus work: 870b84ee-3008-585c-beb0-b3be5c3da867
DOI: 10.1101/2022.09.13.507735

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