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Investigation of 15 of the top candidate genes for late-onset Alzheimer's disease.

Human genetics - 1 Mar 2011

Belbin Olivia, Carrasquillo Minerva M, Crump Michael, Culley Oliver J, Hunter Talisha A, Ma Li, Bisceglio Gina, Zou Fanggeng, Allen Mariet, Dickson Dennis W, Graff-Radford Neill R, Petersen Ronald C, Morgan Kevin, Younkin Steven G

Abstract excerpt

The 12 genome-wide association studies (GWAS) published to-date for late-onset Alzheimer's disease (LOAD) have identified over 40 candidate LOAD risk modifiers, in addition to apolipoprotein (APOE) ε4. A few of these novel LOAD candidate genes, namely BIN1, CLU, CR1, EXOC3L2 and PICALM, have shown consistent replication, and are thus credible LOAD susceptibility genes. To evaluate other promising LOAD candidate...

Topics

Adaptor Proteins, Signal Transducing
Age of Onset
Aged
Aged, 80 and over
Alzheimer Disease
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Source

Open in PubMed Open full text

Identifiers

PMID: 21132329
DOI: 10.1007/s00439-010-0924-2
PMCID: PMC3036835

Genes

GAB2
APOE
BIN1
CLU
EBF3
PICALM
TNK1
GALP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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