Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Investigation of 15 of the top candidate genes for late-onset Alzheimer's disease.

Human genetics - 1 Mar 2011

Belbin Olivia, Carrasquillo Minerva M, Crump Michael, Culley Oliver J, Hunter Talisha A, Ma Li, Bisceglio Gina, Zou Fanggeng, Allen Mariet, Dickson Dennis W, Graff-Radford Neill R, Petersen Ronald C, Morgan Kevin, Younkin Steven G

Abstract excerpt

The 12 genome-wide association studies (GWAS) published to-date for late-onset Alzheimer's disease (LOAD) have identified over 40 candidate LOAD risk modifiers, in addition to apolipoprotein (APOE) ε4. A few of these novel LOAD candidate genes, namely BIN1, CLU, CR1, EXOC3L2 and PICALM, have shown consistent replication, and are thus credible LOAD susceptibility genes. To evaluate other promising LOAD candidate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Age of Onset

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Aged, 80 and over

Share to Alzheimer Disease

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Genotype

Source

Open in PubMed Open full text

Identifiers

PMID: 21132329
DOI: 10.1007/s00439-010-0924-2
PMCID: PMC3036835

Genes

GAB2
APOE
BIN1
CLU
EBF3
PICALM
TNK1
GALP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Investigation of 15 of the top candidate genes for late-onset Alzheimer's disease.PMID 21132329Read ↗

Late-Onset Alzheimer’s Disease Genes and the Potentially Implicated PathwaysSemantic proximity Read ↗

Genetics of Late‐Onset Alzheimer′s Disease: Update from the Alzgene Database and Analysis of Shared PathwaysSemantic proximity Read ↗

Genetic variants influencing human aging from late-onset Alzheimer's disease (LOAD) genome-wide association studies (GWAS).Semantic proximity Read ↗

Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE.Semantic proximity Read ↗

Replication of BIN1 association with Alzheimer's disease and evaluation of genetic interactions.Semantic proximity Read ↗

Genome-wide association study of Alzheimer's disease.Semantic proximity Read ↗

Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease.Semantic proximity Read ↗

Genome-wide analysis of genetic loci associated with Alzheimer disease.Semantic proximity Read ↗

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.Semantic proximity Read ↗

Integrated late onset Alzheimer's disease (LOAD) susceptibility genes: Cholesterol metabolism and trafficking perspectives.Semantic proximity Read ↗

SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians.Semantic proximity Read ↗

Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.