Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Shared genetic etiology underlying Alzheimer's disease and major depressive disorder.

Translational psychiatry - 9 Mar 2020

Lutz Michael W, Sprague Daniel, Barrera Julio, Chiba-Falek Ornit

Abstract excerpt

Patients with late-onset Alzheimer's disease (LOAD) frequently manifest comorbid neuropsychiatric symptoms with depression and anxiety being most frequent, and individuals with major depressive disorder (MDD) have an increased prevalence of LOAD. This suggests shared etiologies and intersecting pathways between LOAD and MDD. We performed pleiotropy analyses using LOAD and MDD GWAS data sets from the International...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Alzheimer's disease research and treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Depressive Disorder, Major

Share to Epigenetics and DNA Methylation

Share to Genetic Associations and Epidemiology

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 32152295
DOI: 10.1038/s41398-020-0769-y
PMCID: PMC7062839

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Shared genetic etiology underlying Alzheimer's disease and major depressive disorder.PMID 32152295Read ↗

Comprehensive analysis of genetic risk loci uncovers novel candidate genes and pathways in the comorbidity between depression and Alzheimer's disease.Semantic proximity Read ↗

Shared genetic etiology underlying late-onset Alzheimer's disease and posttraumatic stress syndrome.Semantic proximity Read ↗

Comprehensive analysis of genetic risk loci uncovers novel candidate genes and pathways in the comorbidity between depression and Alzheimer’s diseaseSemantic proximity Read ↗

Late-Onset Alzheimer’s Disease Genes and the Potentially Implicated PathwaysSemantic proximity Read ↗

The complex genetic architecture of Alzheimer's disease: novel insights and future directions.Semantic proximity Read ↗

Genetic overlap between major depression, bipolar disorder and Alzheimer’s DiseaseSemantic proximity Read ↗

Shared genetic architecture between Alzheimer's disease and psychiatric disorders revealed by multi-trait genome-wide analyses.Semantic proximity Read ↗

Polygenic Risk Score Effectively Predicts Depression Onset in Alzheimer’s Disease Based on Major Depressive Disorder Risk VariantsSemantic proximity Read ↗

Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.Semantic proximity Read ↗

The genetic architecture of dementia risk: how Alzheimer’s disease vulnerability converges on lipid metabolism and immune cell networksSemantic proximity Read ↗

Genome-wide association studies in Alzheimer's disease: a review.Semantic proximity Read ↗

Defining the Genetic Architecture of Alzheimer's Disease: Where Next.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.