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Article

Polygenic Risk Score Reveals Genetic Heterogeneity of Alzheimer's Disease between the Chinese and European Populations.

The journal of prevention of Alzheimer's disease - 1 Jan 2024

Li F, Xie S, Cui J, Li Y, Li T, Wang Y, Jia J

Abstract excerpt

BACKGROUND: The polygenic risk score (PRS) aggregates the effects of numerous genetic variants associated with a condition across the human genome and may help to predict late-onset Alzheimer's disease (LOAD). Most of the current PRS studies on Alzheimer's disease (AD) have been conducted in Caucasian ancestry populations, while it is less studied in Chinese. OBJECTIVE: To establish and examine the validity of...

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Age of Onset
Alzheimer Disease
Amyloid beta-Peptides
East Asian People
Genetic Heterogeneity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Risk Score

Multifactorial Inheritance

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PMID: 38706286
DOI: 10.14283/jpad.2024.29

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APOE

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