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Article

Polygenic risk discriminates Lewy body dementia from Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Feb 2025

McKeever Anna, Swann Peter, Malpetti Maura, Donaghy Paul C, Thomas Alan, Mak Elijah, Carter Stephen F, Tan Jerry H K, Hong Young T, Fryer Tim D, Heslegrave Amanda, Zetterberg Henrik, Su Li, Chouliaras Leonidas, Rowe James B, O'Brien John T

Abstract excerpt

INTRODUCTION: Lewy body dementia (LBD) shares genetic risk factors with Alzheimer's disease (AD), including apolipoprotein E (APOE), but is distinguishable at the genome-wide level. Polygenic risk scores (PRS) may therefore improve diagnostic classification. METHODS: We assessed diagnostic classification using AD-PRS excluding APOE (AD-PRSno APOE), APOE risk score (APOE-RS), and plasma phosphorylated tau 181...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39853853
DOI: 10.1002/alz.14381
PMCID: PMC11848393

Genes

APOE

Provenance

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