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Article

Association of whole-person eigen-polygenic risk scores with Alzheimer's disease.

Human molecular genetics - 22 Jul 2024

Kharaghani Amin, Tio Earvin S, Milic Milos, Bennett David A, De Jager Philip L, Schneider Julie A, Sun Lei, Felsky Daniel

Abstract excerpt

Late-Onset Alzheimer's Disease (LOAD) is a heterogeneous neurodegenerative disorder with complex etiology and high heritability. Its multifactorial risk profile and large portions of unexplained heritability suggest the involvement of yet unidentified genetic risk factors. Here we describe the "whole person" genetic risk landscape of polygenic risk scores for 2218 traits in 2044 elderly individuals and test if...

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Aged
Aged, 80 and over
Alzheimer Disease
Amyloid beta-Peptides
Apolipoproteins E

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Cognitive Dysfunction

Genetic Risk Score

Genome-Wide Association Study

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Identifiers

PMID: 38679805
DOI: 10.1093/hmg/ddae067
PMCID: PMC11262744

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