Article
Risk prediction of late-onset Alzheimer's disease implies an oligogenic architecture.
Nature communications - 23 Sept 2020
Zhang Qian, Sidorenko Julia, Couvy-Duchesne Baptiste, Marioni Riccardo E, Wright Margaret J, Goate Alison M, Marcora Edoardo, Huang Kuan-Lin, Porter Tenielle, Laws Simon M, Sachdev Perminder S, Mather Karen A, Armstrong Nicola J, Thalamuthu Anbupalam, Brodaty Henry, Yengo Loic, Yang Jian, Wray Naomi R, McRae Allan F, Visscher Peter M
Abstract excerpt
Genetic association studies have identified 44 common genome-wide significant risk loci for late-onset Alzheimer's disease (LOAD). However, LOAD genetic architecture and prediction are unclear. Here we estimate the optimal P-threshold (Poptimal) of a genetic risk score (GRS) for prediction of LOAD in three independent datasets comprising 676 cases and 35,675 family history proxy cases. We show that the...
Topics
Join the communities discussing this publication.