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Harnessing the paradoxical phenotypes of APOE ɛ2 and APOE ɛ4 to identify genetic modifiers in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 May 2021

Kim Young Won, Al-Ramahi Ismael, Koire Amanda, Wilson Stephen J, Konecki Daniel M, Mota Samantha, Soleimani Shirin, Botas Juan, Lichtarge Olivier

Abstract excerpt

The strongest genetic risk factor for idiopathic late-onset Alzheimer's disease (LOAD) is apolipoprotein E (APOE) ɛ4, while the APOE ɛ2 allele is protective. However, there are paradoxical APOE ɛ4 carriers who remain disease-free and APOE ɛ2 carriers with LOAD. We compared exomes of healthy APOE ɛ4 carriers and APOE ɛ2 Alzheimer's disease (AD) patients, prioritizing coding variants based on their predicted...

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PMID: 33576571
DOI: 10.1002/alz.12240
PMCID: PMC8247413

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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