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Harnessing the paradoxical phenotypes of APOE ɛ2 and APOE ɛ4 to identify genetic modifiers in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 May 2021

Kim Young Won, Al-Ramahi Ismael, Koire Amanda, Wilson Stephen J, Konecki Daniel M, Mota Samantha, Soleimani Shirin, Botas Juan, Lichtarge Olivier

Abstract excerpt

The strongest genetic risk factor for idiopathic late-onset Alzheimer's disease (LOAD) is apolipoprotein E (APOE) ɛ4, while the APOE ɛ2 allele is protective. However, there are paradoxical APOE ɛ4 carriers who remain disease-free and APOE ɛ2 carriers with LOAD. We compared exomes of healthy APOE ɛ4 carriers and APOE ɛ2 Alzheimer's disease (AD) patients, prioritizing coding variants based on their predicted...

Topics

Alzheimer Disease
Animals
Apolipoprotein E2
Apolipoprotein E4
Brain
Drosophila
Heterozygote
Homozygote
Humans
Mutation
Phenotype

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PMID: 33576571
DOI: 10.1002/alz.12240
PMCID: PMC8247413

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