Article
Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Feb 2018
Cruchaga Carlos, Del-Aguila Jorge L, Saef Benjamin, Black Kathleen, Fernandez Maria Victoria, Budde John, Ibanez Laura, Deming Yuetiva, Kapoor Manav, Tosto Giuseppe, Mayeux Richard P, Holtzman David M, Fagan Anne M, Morris John C, Bateman Randall J, Goate Alison M, Harari Oscar
Abstract excerpt
OBJECTIVE: To determine whether the extent of overlap of the genetic architecture among the sporadic late-onset Alzheimer's Disease (sLOAD), familial late-onset AD (fLOAD), sporadic early-onset AD (sEOAD), and autosomal dominant early-onset AD (eADAD). METHODS: Polygenic risk scores (PRSs) were constructed using previously identified 21 genome-wide significant loci for LOAD risk. RESULTS: We found that there is...
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