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Article

Molecular basis of CTCF binding polarity in genome folding.

Nature communications - 5 Nov 2020

Nora Elphège P, Caccianini Laura, Fudenberg Geoffrey, So Kevin, Kameswaran Vasumathi, Nagle Abigail, Uebersohn Alec, Hajj Bassam, Saux Agnès Le, Coulon Antoine, Mirny Leonid A, Pollard Katherine S, Dahan Maxime, Bruneau Benoit G

Abstract excerpt

Current models propose that boundaries of mammalian topologically associating domains (TADs) arise from the ability of the CTCF protein to stop extrusion of chromatin loops by cohesin. While the orientation of CTCF motifs determines which pairs of CTCF sites preferentially stabilize loops, the molecular basis of this polarity remains unclear. By combining ChIP-seq and single molecule live imaging we report that...

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Identifiers

PMID: 33154377
DOI: 10.1038/s41467-020-19283-x
PMCID: PMC7645679

Genes

CTCF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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