Article

Dosage sensitivity of the loop extrusion rate confers tunability to genome folding while creating vulnerability to genetic disruption

2025-08-15

Abstract excerpt

Genome folding is not static, but emerges from dynamic processes that control transcription, replication, recombination, and repair. DNA loop extrusion by cohesin is central to genome organization, yet it remains unclear how cells can tune extrusion kinetics to achieve precise and functional chromosome folding patterns. Here we discover extrusion rate acts as a tunable biophysical parameter in cells, quantitativel...

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Literature Corpus work: 0a571d5e-cede-5f57-b724-1c283fd18f75
DOI: 10.1101/2025.08.14.667581

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