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Cohesin acetylation and ATPase activity control cohesion and loop architecture through distinct mechanisms.

Proceedings of the National Academy of Sciences of the United States of America - 28 Apr 2026

Costantino Lorenzo, Ye Tiantian, Boardman Kevin, Xiang Siheng, Luo Jonathan, Mu Yudi, Ma Wenxiu, Koshland Douglas

Abstract excerpt

Cohesin is a conserved protein complex that mediates sister chromatid cohesion, chromosome condensation, gene regulation, and DNA repair. These processes rely on cohesin's ability to tether DNA and form chromatin loops, which depend on cohesin's ATP hydrolysis activity and Eco1-mediated acetylation of two lysines (K112 and K113 in budding yeast) in its Smc3 subunit. However, how cohesin's ATPase activity and...

Topics

Cell Cycle Proteins
Acetylation
Chromosomal Proteins, Non-Histone
Cohesins
Adenosine Triphosphatases
Saccharomyces cerevisiae Proteins
Saccharomyces cerevisiae
Nuclear Proteins
Chromatin
Chromatids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Lysine

Acetyltransferases

Source

Open in PubMed Open full text

Identifiers

PMID: 42018406
DOI: 10.1073/pnas.2531218123
PMCID: PMC13123822

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Cohesin acetylation and ATPase activity control cohesion and loop architecture through distinct mechanisms.PMID 42018406Read ↗

Closing the cohesin ring: structure and function of its Smc3-kleisin interface.Semantic proximity Read ↗

Controlling mechanism of the Scc2-cohesin interaction to restrict peri-centromeric DNA loop expansion and facilitate mitotic chromosome segregationSemantic proximity Read ↗

Pds5 regulates sister chromatid cohesion by controlling cohesin ATPase activity through the Eco1-Smc3 acetylation pathway.Semantic proximity Read ↗

Genetic evidence that the acetylation of the Smc3p subunit of cohesin modulates its ATP-bound state to promote cohesion establishment in Saccharomyces cerevisiae.Semantic proximity Read ↗

PCNA promotes context-specific sister chromatid cohesion establishment separate from that of chromatin condensation.Semantic proximity Read ↗

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More to cohesin than meets the eye: complex diversity for fine-tuning of function.Semantic proximity Read ↗

Building sister chromatid cohesion: smc3 acetylation counteracts an antiestablishment activity.Semantic proximity Read ↗

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Cohesin's ATPase activity couples cohesin loading onto DNA with Smc3 acetylation.Semantic proximity Read ↗

Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion.Semantic proximity Read ↗

Region-specific generation and retention of acetylated cohesin shape the genome-wide pattern of sister chromatid cohesionSemantic proximity Read ↗

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