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Article

Absolute quantification of cohesin, CTCF and their regulators in human cells

2019-02-26

Abstract excerpt

The organisation of mammalian genomes into loops and topologically associating domains (TADs) contributes to chromatin structure, gene expression and recombination. Loops and TADs are formed by cohesin and positioned by CTCF. In proliferating cells, cohesin also mediates sister chromatid cohesion, which is essential for chromosome segregation. Current models of chromatin folding and cohesion are based on assumptio...

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Identifiers and source

Literature Corpus work
64116e67-2c53-5df5-85ac-b340ecddde14
DOI
10.1101/560425
Open publication

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