CTCF chromatin residence time controls three-dimensional genome organization, gene expression and DNA methylation in pluripotent cells.

doi:10.1038/s41556-021-00722-w

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CTCF chromatin residence time controls three-dimensional genome organization, gene expression and DNA methylation in pluripotent cells.

Nature cell biology - 1 Aug 2021

Soochit Widia, Sleutels Frank, Stik Gregoire, Bartkuhn Marek, Basu Sreya, Hernandez Silvia C, Merzouk Sarra, Vidal Enrique, Boers Ruben, Boers Joachim, van der Reijden Michael, Geverts Bart, van Cappellen Wiggert A, van den Hout Mirjam, Ozgur Zeliha, van IJcken Wilfred F J, Gribnau Joost, Renkawitz Rainer, Graf Thomas, Houtsmuller Adriaan, Grosveld Frank, Stadhouders Ralph, Galjart Niels

Abstract excerpt

The 11 zinc finger (ZF) protein CTCF regulates topologically associating domain formation and transcription through selective binding to thousands of genomic sites. Here, we replaced endogenous CTCF in mouse embryonic stem cells with green-fluorescent-protein-tagged wild-type or mutant proteins lacking individual ZFs to identify additional determinants of CTCF positioning and function. While ZF1 and ZF8-ZF11 are...

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PMID: 34326481
DOI: 10.1038/s41556-021-00722-w

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