Article

Universal dynamics of cohesin-mediated loop extrusion

2024-08-10

Abstract excerpt

Most animal genomes are partitioned into Topologically Associating Domains (TADs), created by cohesin-mediated loop extrusion and defined by convergently oriented CTCF sites. The dynamics of loop extrusion and its regulation remains poorly characterized in vivo . Here, we tracked TAD anchors in living human cells to visualize and quantify cohesin-dependent loop extrusion across multiple endogenous genomic regions...

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Literature Corpus work: 2472f64b-0f67-5312-b643-50353e90874d
DOI: 10.1101/2024.08.09.605990

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