Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The microtubule regulator EFA-6 forms cortical foci dependent on its intrinsically disordered region and interactions with tubulins.

Cell reports - 22 Oct 2024

Sandhu Anjali, Lyu Xiaohui, Wan Xinghaoyun, Meng Xuefeng, Tang Ngang Heok, Gonzalez Gilberto, Syed Ishana N, Chen Lizhen, Jin Yishi, Chisholm Andrew D

Abstract excerpt

The EFA6 protein family, originally identified as Sec7 guanine nucleotide exchange factors, has also been found to regulate cortical microtubule (MT) dynamics. Here, we find that in the mature C. elegans epidermal epithelium, EFA-6 forms punctate foci in specific regions of the apical cortex, dependent on its intrinsically disordered region (IDR). The EFA-6 IDR can form biomolecular condensates in vitro. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanine Nucleotide Exchange Factors

Share to Intrinsically Disordered Proteins

Share to Microtubules

Share to Mutation

Share to Protein Binding

Share to Tubulin

Source

Identifiers

PMID: 39305484
DOI: 10.1016/j.celrep.2024.114776

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The microtubule regulator EFA-6 forms cortical foci dependent on its intrinsically disordered region and interactions with tubulins.PMID 39305484Read ↗

The disease-associated formin INF2/EXC-6 organizes lumen and cell outgrowth during tubulogenesis by regulating F-actin and microtubule cytoskeletons.Semantic proximity Read ↗

The endoplasmic reticulum promotes microtubule organization and region-specific disassembly to execute Compartmentalized Cell EliminationSemantic proximity Read ↗

Artificial Intelligence-Enabled AlphaFold II Pipeline Guides Functional Fluorescence Labeling of Tubulin Across SpeciesSemantic proximity Read ↗

Prefoldin 6 is required for normal microtubule dynamics and organization in Arabidopsis.Semantic proximity Read ↗

The Caenorhabditis elegans microtubule minus-end binding homolog PTRN-1 stabilizes synapses and neurites.Semantic proximity Read ↗

Epidermal cell fusion promotes the transition from an embryonic to a larval transcriptome in C. elegans.Semantic proximity Read ↗

Biallelic TBCD Mutations Cause Early-Onset Neurodegenerative Encephalopathy.Semantic proximity Read ↗

Modeling a disease-correlated tubulin mutation in budding yeast reveals insight into MAP-mediated dynein function.Semantic proximity Read ↗

PTRN-1, a microtubule minus end-binding CAMSAP homolog, promotes microtubule function in Caenorhabditis elegans neurons.Semantic proximity Read ↗

Distinct effects of tubulin isotype mutations on neurite growth in Caenorhabditis elegans.Semantic proximity Read ↗

Novel α-tubulin mutation disrupts neural development and tubulin proteostasis.Semantic proximity Read ↗

GCP6 binds to intermediate filaments: a novel function of keratins in the organization of microtubules in epithelial cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.